Lexapro and Ambien – Drug Interactions

Some people who tend to suffer from insomnia associated with anxiety or depression are always in the lookout for another drug to be combined with Ambien to eliminate their illness. The main reason why they need another drug is that Ambien works only on insomnia and that it can’t help users overcome anxiety or depression in these cases. This scenario forces the users to explore an antidepressant that could not produce much of any side effects with Ambien. Lexapro is one of the popular choices of most people who tend to combine both Lexapro and Ambien for their anxiety associated with insomnia conditions.

Ambien is a brain chemical inhibitor that decreases the signs of agitation and excitation in the brain nerves. Hence, the active ingredient of Ambien binds with the neurochemical called GABA, to increase its activity for suppression of excitation leading to relaxation and calmness. However, Lexapro follows a similar line of action by selective inhibition of serotonin reuptake. This is why Lexapro and Ambien could be combined for consumption in special cases though Ambien is always not recommended for usage with anti-depressants.

Ambien helps to keep the sleep cycle normal and prevent sleep deprivation if it’s taken 2 hours before bedtime. The active ingredient of this pill Zolpidem has absorption traits thereby the effectiveness of the drug starts after a few minutes of the intake.

Also, on interaction, the increased effects of Lexapro might be evident and at times the dosage of Lexapro is increased by keeping Ambien dosage very minimal, depending upon the doctor. But these drugs promote addiction and withdrawal symptoms and hence, the long term effects of these drugs is still unknown and the drugs must be combined only with after the consultation of a health professional under his/her supervision.

Both Ambien and Lexapro’s mechanism of action kicks in very faster after absorption and hence the effects are visible within 1 hour from usage.

Rules for Combining Lexapro and Ambien

Ambien and Lexapro can be combined simultaneously only after the prescription of the doctor.

Basic recommendation for use of Lexapro and Ambien

  • These drugs can be taken with an hour gap between their consumption before bedtime.
  • Consumption of Lexapro and Ambien above the prescribed doses can cause serious side effects.
  • It is better to avoid any activities of mental alertness after the consumption of these drugs since they can be highly sedating and lead to serious injuries.
  • Avoid the consumption of alcohol along with Lexapro and Ambien since it can cause adverse effects.
  • Do not stop using these drugs without the consultation of a doctor.


The risks involved in the drug interactions of Lexapro and Ambien can differ from individual to individual and hence they can be grouped under major, minor and moderate risks based on the effects. The common side effects are drowsiness, dizziness, headache and confusion.

However, the interaction of these drugs could be very fatal for some of the people who have experienced these disorders or come under these conditions.

  • Low levels of sodium, potassium and magnesium in the blood
  • History of liver and kidney ailment.
  • Serious respiratory depression
  • Seizures
  • Suicidal thoughts
  • Heart disease
  • Psychotic Illness
  • Myasthenia Gravis
  • Fatigue
  • Stomach bleeding

These are some of the contraindications while there might be a lot more, which you could consult a physician and get to know about it.

Brief description on Lexapro

Lexapro is an orally administered drug effective for the treatment of anxiety and depression. The action of Lexapro works through the inhibition of selective serotonin reuptake. Hence, it helps in striking the balance of the chemical substance in the brain called serotonin to promote calmness, energy levels and well-being.